Endocrine Abstracts

Background: The Insulin Tolerance Test (ITT) is the gold standard for assessing pituitary function in adults, but used variably in paediatrics due to concerns of serious adverse events. Our aim was to assess the safety of ITT and identify factors associated with the hypoglycaemic response.Methods: We retrospectively collected the following data from patients who underwent ITT (n=122) under Paediatric Endocrinology from 2019-2021: demography, ant...

Background: The short synacthen test (SST) is commonly used to evaluate the integrity of the hypothalamic–pituitary–adrenal (HPA) axis in children. However, this test is time-consuming, requiring cannulation, several blood samples, and medical observation. Studies in adults have suggested an early morning serum cortisol level could be used to rule out or confirm adrenal insufficiency, reducing reliance on SSTs, however, few studies have evaluated thi...